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SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103
In a phase 2 obesity trial, retatrutide demonstrated an average weight loss of 17.5% at 24 weeks and 24.2% at 48 weeks in the 12 mg dose group 7
MEDICAL WEIGHT LOSS Q&A WHAT ARE THE BENEFITS OF LOSING WEIGHT
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